CYTOO has developed a first-in-class kidney proximal tube model. This model presents in vivo like characteristics such as cell polarization and formation of a true lumen, together with a high level of key tubular transporter genes.

Features

Fully polarized  proximal tubules, closed lumen, hundreds of structures per well more mature phenotype, high level of megalin, OAT1, OCT2 and CYP3A4 expression. 

Applications

Nephrotoxicity, kidney diseases

Advantages

Robustness, high Z’, HCA compatible

Our renal proximal tube cellular model can be in-licensed should you wish to further develop novel HCA compatible read-outs and assays. CYTOO also offers custom cellular model and cell-based assay development through research contracts.

For more information on our cellular models and Cell-Based Assays, please contact us. For business options and terms, click here.