Based on cardio-specific micropatterns, we have reconstituted a more physiological environment and a higher level of maturation of human iPS- derived cardiomyocytes that can be organized and connected to reconstitute cardiac fibers. In such context, cardiomyocytes present a better sarcomere alignment, an increase in Connexin 43 expression and synchronous cell beating. Taking advantage of these important features, we are setting up hypertrophy, Ca2+ flux and cell beating assays.

Features

Aligned sarcomeres, single cell or connected cells, high level of connexin 43 expression           

Applications

Cardiotoxicity, electrophysiology, beating, hypertrophy, contractility, fibrosis

Advantages

Standardized morphology, robustness, HCA compatibility, synchronized beating

Our cardiomyocyte cellular model can be in-licensed should you wish to further develop novel HCA compatible read-outs and assays. CYTOO also offers custom cellular model and cell-based assay development through research contracts.

We also offer a fee-for service should you wish to screen your compounds for cardiac toxicity (Ca2+ flux, cell beating, contractility, hypertrophy, fibrosis).

For more information on our cellular models and Cell-Based Assays, please contact us. For business options and terms, click here.